Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12
نویسندگان
چکیده
منابع مشابه
Role of IL12 in MAIDS.
Cousens, LP, Orange, J.S. & Biron, CA. (1995), EndogeWysocka, M., Kubin, M., Vieria, L.Q., Ozmen, L., nous interleukin-2 (IL-2) contributes to T cell expanGarotta, G., Scott, P. & Trinchieri, G. (1995), Intersion and interferon y (IFN-y) production during leukin-12 is required for interferon-y production and lymphocytic choriomeningitis virus infection. J. lethality in lipopolysaccharide-induce...
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چکیده ندارد.
Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma
BACKGROUND Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as anti-cancer agent. Systemic administration of IL-12 often results in unacceptable toxicity; therefore, strategies to direct delivery of IL-12 to tumors are under investigation. The objective of this study was to assist the preclini...
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Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe toxicity hampering their application to therapeutically active regimens. This problem can be overcome by using immunocytokines (cytokines fused to antibody or antibody fragments) which selectively deliver the active cytokine to the tumor enviro...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2020
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-20-0484